Welcome to the Computational BioSystems Lab

at the University of Alberta

We study questions at the interface between cell biology, physiology and engineering using a range of computational and theoretical techniques. Often, these questions require the development of new methods for simulating complex systems across disparate length and time scales. More detailed descriptions of our research can be found here.

Information about our research team can be found here. If you are interested in joining the Computational BioSystems Lab, more information can be found here.

Meet the Team

Principal Investigator


Wylie Stroberg

Assistant Professor of Mechanical Engineering

Computational Biology, Multiscale Simulation, Nanofluidics

Graduate Students


Ali Bigdeli

PhD Student, Mechanical Engineering

Multiscale modeling of GLAD-based enzymatic nanosensors


Emad Ghazizadeh

PhD Student, Mechanical Engineering

Protein-based modulation of endoplasmic reticulum shape


Md. Zobayer Hossein

MSc Student

Induction of the unfolded protein response through membrane surface tension


Sara Sheikhi

PhD Student, Mechanical Engineering (joint w/ Prof. Hogan)

Development of new interatomic potentials for advanced ceramics using machine learning

Undergraduate Researchers


Alexander Detkov

BSc Student, Engineering Physics

Nanoscale flow of polymeric solutions


The overarching aim of our lab is to bring new quantitative techniques to problems in biology and nanotechnology. Below you will find examples of our research projects.

Systems Biology of Proteostasis and the Unfolded Protein Response

We are deciphering the control mechanism of the unfolded protein response and protein homeostasis to open new therapeutic avenues for age-associated and protein folding diseases

Reactions in Crowded Cellular Compartments

The study of macromolecular crowding is indispensable for understanding cellular physiology and biochemistry. We are investigating how crowding affects quantitatively the cellular biochemistry, and qualitatively cellular physiology.

Wetting Phenomena of Nanoscale Structures

We are using mesoscopic simulations to investigate wetting and transport properties of complex fluids at the nanoscale.


  • Donadeo Innovation Centre for Engineering, 9211-116 Street NW, Edmonton, AB T6G 1H9