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Manuscript Title: Concentration Sensing in Crowded Environments Concentration Sensing in Crowded Environments

Signal transduction within crowded cellular compartments is essential for the physiological function of cells and organisms. While the accuracy with which receptors can probe the concentration of ligands has been thoroughly investigated in dilute …

Characteristic, completion or matching timescales? An analysis of temporary boundaries in enzyme kinetics

Scaling analysis exploiting timescale separation has been one of the most important techniques in the quantitative analysis of nonlinear dynamical systems in mathematical and theoretical biology. In the case of enzyme catalyzed reactions, it is often …

Information processing by endoplasmic reticulum stress sensors

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license. The unfolded protein response (UPR) is a collection of …

Characteristic, completion or matching timescales? an analysis of temporary boundaries in enzyme kinetics

Copyright textcopyright 2018, arXiv, All rights reserved. Scaling analysis exploiting timescale separation has been one of the most important techniques in the quantitative analysis of nonlinear dynamical systems in mathematical and theoretical …

Do Cellular Condensates Accelerate Biochemical Reactions? Lessons from Microdroplet Chemistry

Cellular condensates—phase-separated concentrates of proteins and nucleic acids—provide organizational structure for biochemistry that is distinct from membrane-bound compartments. It has been suggested that one major function of cellular condensates …

How to design an optimal sensor network for the unfolded protein response

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license. Cellular protein homeostasis requires continuous …

Theory of the reactant-stationary kinetics for a coupled auxiliary enzyme assay

Copyright textcopyright 2018, ChemRxiv, All rights reserved. A theoretical analysis is performed on the nonlinear ordinary differential equations that govern the dynamics of a coupled auxiliary enzyme catalyzed reaction. The assay consists of a …

Gonadotropin-Releasing Hormone (GnRH) Neuron Excitability Is Regulated by Estradiol Feedback and Kisspeptin

Gonadotropin-releasing hormone (GnRH) neurons produce the central output controlling fertility and are regulated by steroid feedback. A switch from estradiol negative to positive feedback initiates the GnRH surge, ultimately triggering ovulation. …

On the validity and errors of the pseudo-first-order kinetics in ligand–receptor binding

The simple bimolecular ligand–receptor binding interaction is often linearized by assuming pseudo-first-order kinetics when one species is present in excess. Here, a phase-plane analysis allows the derivation of a new condition for the validity of …

On the estimation errors of KM and V from time-course experiments using the Michaelis–Menten equation

The conditions under which the Michaelis–Menten equation accurately captures the steady-state kinetics of a simple enzyme-catalyzed reaction is contrasted with the conditions under which the same equation can be used to estimate parameters, KM and V, …